ALOGLIPTIN INTERMEDIATE BY A.R. LIFE SCIENCE

Alogliptin Intermediate by A.R. Life Science

Alogliptin Intermediate by A.R. Life Science

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Alogliptin Intermediate: (R)-3-Piperidinamine Dihydrochloride and Its Role in Diabetes Treatment


Pharmaceutical advancements depend on precise chemical intermediates that synthesise life-changing medications. One critical compound is (R)-3-Piperidinamine Dihydrochloride, bearing CAS No. 334618-23-4. This intermediate is vital in producing Alogliptin, a widely used drug for managing type 2 diabetes mellitus.

We provide an in-depth look into the properties, mechanism of action, therapeutic uses, and significance of (R)-3-Piperidinamine Dihydrochloride in the pharmaceutical industry.

  • Overview of (R)-3-Piperidinamine Dihydrochloride

  • Chemical Name: (R)-3-Piperidinamine Dihydrochloride

  • CAS Number: 334618-23-4

  • Molecular Formula: C5H14Cl2N2

  • Molecular Weight: 173.09 g/mol


Properties



  • Appearance: White crystalline powder.

  • Solubility: Highly soluble in water and polar organic solvents like ethanol.

  • Stability: Stable under standard conditions; sensitive to extreme humidity.

  • This intermediate is characterized by its piperidine ring structure, which is essential for forming the molecular framework of Alogliptin.


Role in Alogliptin Synthesis


(R)-3-Piperidinamine Dihydrochloride is a key intermediate used in the multi-step synthesis of Alogliptin. Its stereochemistry and chemical reactivity are crucial for constructing Alogliptin's active pharmaceutical structure.

Mechanism of Action of Alogliptin


Alogliptin belongs to the class of DPP-4 (dipeptidyl peptidase-4) inhibitors. It works by increasing the body's natural ability to regulate blood sugar levels.

How It Works:


Inhibition of DPP-4: Alogliptin blocks the DPP-4 enzyme, which breaks down incretin hormones such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide).

Prolongation of Incretin Activity: This results in increased insulin secretion and decreased glucagon release in a glucose-dependent manner.

Better Glycemic Control: Helps maintain stable blood glucose levels, especially after meals.

Alogliptin is often used in combination with other medications to provide comprehensive diabetes management.

Therapeutic Applications


Alogliptin, synthesized using (R)-3-Piperidinamine Dihydrochloride, is primarily used for:

Type 2 Diabetes Mellitus


Helps control high blood sugar levels when used with a proper diet and exercise regimen.

Combination Therapy

Frequently combined with metformin, sulfonylureas, or thiazolidinediones to improve glycemic outcomes.

Reduction of Diabetes-Related Risks

Lowers the risk of complications such as cardiovascular diseases, neuropathy, and retinopathy associated with poorly managed diabetes.

Importance of High-Quality Intermediates


The quality of (R)-3-Piperidinamine Dihydrochloride significantly impacts the safety, efficacy, and reliability of Alogliptin. High-purity intermediates ensure:

Precision in molecular synthesis.


Consistency in drug performance.

Adherence to stringent global pharmaceutical standards.

Manufacturing Excellence in Intermediates

Manufacturers specializing in (R)-3-Piperidinamine Dihydrochloride play a pivotal role in the pharmaceutical supply chain. By implementing advanced technologies, rigorous quality control measures, and innovative synthesis methods, they ensure that intermediates meet the exacting requirements of drug manufacturers.

Conclusion


(R)-3-Piperidinamine Dihydrochloride (CAS No. 334618-23-4) is a vital intermediate in the production of Alogliptin, a highly effective DPP-4 inhibitor for managing type 2 diabetes. Its precise role in Alogliptin synthesis underscores the importance of high-quality intermediates in producing safe and reliable medications.

With its ability to support the development of cutting-edge diabetes therapies, this intermediate contributes to the global fight against a chronic condition that affects millions. Reliable manufacturers of (R)-3-Piperidinamine Dihydrochloride are key partners in advancing healthcare and improving the quality of life for patients worldwide.

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